PERT Brands: Comparing Your Options
Several FDA-approved pancreatic enzyme replacement products are available. While they all contain the same basic enzymes, there are differences in strengths, formulations, and costs that may influence which works best for you.
Key Insight
All FDA-approved PERT products contain porcine-derived enzymes with similar effectiveness. The main differences are in available strengths, capsule size, coating technology, and cost. Your doctor can help determine which brand suits your specific needs.
FDA-Approved PERT Brands
| Brand | Manufacturer | Lipase Strengths (USP units) |
|---|---|---|
| Creon | AbbVie | 3,000 / 6,000 / 12,000 / 24,000 / 36,000 |
| Zenpep | Nestle Health Science | 3,000 / 5,000 / 10,000 / 15,000 / 20,000 / 25,000 / 40,000 |
| Pancreaze | Vivus | 4,200 / 10,500 / 16,800 / 21,000 |
| Pertzye | Chiesi | 8,000 / 16,000 |
| Viokace | Nestle Health Science | 10,440 / 20,880 |
*Strengths listed are lipase units per capsule. All products also contain protease and amylase.
Factors to Consider
Cost & Insurance
PERT is expensive without insurance. Check your plan's formulary to see which brands are covered. Patient assistance programs are available from most manufacturers.
Strength Options
Having the right strength options lets you fine-tune your dose. Zenpep offers the widest range, which can be helpful for precise dosing.
Capsule Size
If you have difficulty swallowing, compare capsule sizes. Some brands have smaller capsules for the same strength.
Response & Tolerance
Some patients respond better to one brand than another, even though they're similar. If one doesn't work well, trying a different brand is reasonable.
Important Notes
- • Don't switch brands without consulting your doctor – Doses may need adjustment
- • Generic PERT is not available – All products are brand-name only
- • Pork-derived – All FDA-approved products come from porcine sources
- • Not interchangeable – Pharmacy cannot substitute one brand for another without prescriber approval
Get Complete PERT Guidance
Our comprehensive book covers everything about optimizing your enzyme therapy.
Get the Book on Amazon